Absolutely. One of the reasons I love Donna so is because Donna and The Doctor were both so good for each other. They were friends in the best way, and though I know there was nothing "romantic" there, I could totally see something (not traditionally) romantic developing because they were such good friends and so good for each other.
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(No one was ever better for the Doctor than Donna.)
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I miss Donna.
Gonna watch "The End of Time" later this weekend.